Oligonucleotide Purification
Oligonucleotide Solutions
Complete purification workflows for ASO, siRNA, and modified oligonucleotides. Our specialized chromatography resins deliver high purity and recovery for therapeutic and research applications.
Platform Process
Standard 4-step purification workflow
1
Cleanup
Boronate Affinity
2
IEX
Anion Exchange
3
RP
Reversed Phase
4
Final
Desalting
Oligonucleotide Downstream Purification Process
Multi-Modal Chromatography Strategy
Monomix HC60-Boronate
Monomix HC60-DEAE Excel
PolyRP
Bio-C18
SEC Resins
Crude
Cleanup
Ion
Exchange
Reversed
Phase
Final
Desalting
Formulation
Removal of synthesis reagents and short fragments
Separation based on charge and length
High-resolution purification
Buffer exchange and concentration
Drug product ready
Oligonucleotide Applications
Explore specialized workflows optimized for each oligonucleotide format. Click on categories to expand and discover related products.
Recommended Products
Key resins for oligonucleotide purification workflows.